國家理論科學研究中心

分子演化數學 2006春季專題課程

主講人:       Dr. Yun-Huei Tzeng 曾雲輝 (中研院基因體中心)
 
地點:          新竹市清華大學綜合三館一樓 R101

上課時間 :  2006年春季，每星期一 ，上午9:00-12:00。

                 第一次上課時間: 二月二十日開始。

                 清華大學數學系開課課號 MATH 3100

課程簡介 : 

1. Introduction to Population. Genetics
   1.1 Natural Selection
   1.2 Random Genetic Drift
   1.3 Selection and Mutation
   1.4 The Fundamental Theorem of Natural Selection

2. Dynamics of Nucleotide Substitution
   2.1 Jukes and Cantor’s One-parameter Model
   2.2 Kimura’s Two-Parameter Model
   2.3 General Models

3. Estimating the Number of Nucleotide Substitutions Between Sequences
   3.1 Divergence Between DNA Sequences
   3.2 Noncoding Sequences with Uniform Substitution Rate
   3.3 Protein-Coding Sequences

4. Computational Molecular Biology
   4.1 Comparing Two Sequences --- The Basic Algorithm
   4.2 Database Search --- BLAST
   4.3 Phylogenetic Trees
　

參考書目:

1. Motoo Kimura (1983) "The Neutral Theory of Molecular Evolution",  

    Cambridge University Press.
2. Joao Setubal and Joao Meidanis (1997) "Introduction to Computational
    Molecular Biology" University of Campinas, Brazil.
3. Wen-Hsiung Li (1997) "Molecular Evolution", Sinauer Associates.